Spectroscopic studies of interactions between dyes and model molecules of Alzheimer's disease

A. Elhaddaoui; A. Delacourte; S. Turrell

doi:10.1117/12.146198

17 June 1993 Spectroscopic studies of interactions between dyes and model molecules of Alzheimer's disease

A. Elhaddaoui, A. Delacourte, S. Turrell

Proceedings Volume 1922, Laser Study of Macroscopic Biosystems; (1993) https://doi.org/10.1117/12.146198
Event: Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, 1992, Jyvaskyla, Finland

Abstract

Raman, FTIR, fluorescence, and UV-visible spectra are used to study interactions between amuloid-labelling dyes and poly-L-lysine and bovine insulin, two proteins which play the role of models of (beta) amyloid of Alzheimers disease. It is found that though the (beta) conformation of the peptide is not essential, it helps to encourage binding which appears to be stable and specific in nature, involving SO₃- groups of the dyes and NH₂ groups of the proteins.

Citation Download Citation

A. Elhaddaoui, A. Delacourte, and S. Turrell "Spectroscopic studies of interactions between dyes and model molecules of Alzheimer's disease", Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); https://doi.org/10.1117/12.146198

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