Dosimetry and light distribution systems for photodynamic therapy at the Norwegian Radium Hospital

Helen Heyerdahl; Trond Warloe; Qian Peng; Katarina Svanberg M.D.; Johan Moan; Harald B. Steen; Lars Othar Svaasand; Karl-Erik Giercksky

doi:10.1117/12.168711

1 March 1994 Dosimetry and light distribution systems for photodynamic therapy at the Norwegian Radium Hospital

Helen Heyerdahl, Trond Warloe, Qian Peng, Katarina Svanberg M.D., Johan Moan, Harald B. Steen, Lars Othar Svaasand, Karl-Erik Giercksky

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168711
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Photodynamic therapy has been used for treatment of malignant cutaneous lesions. Photosensitizer has been topically applied, 5-aminolevulinic acid, with light delivered at 630 nm. A study of response rate to varying light doses was performed, it might seem that light doses of 40 - 50 J/cm² is sufficient for superficial lesions. For nodular lesions higher light doses are needed. Some patients with tumors in the gastrointestinal tract have been treated with systemic administration of 5-aminolevulinic acid and re-treated with Photofrin in case of unsatisfactory results. From the preliminary material available 5-aminolevulinic acid seems less promising as a photosensitizer for internal lesions compared to dermal lesions.

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Helen Heyerdahl, Trond Warloe, Qian Peng, Katarina Svanberg M.D., Johan Moan, Harald B. Steen, Lars Othar Svaasand, and Karl-Erik Giercksky "Dosimetry and light distribution systems for photodynamic therapy at the Norwegian Radium Hospital", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168711

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