Is the photobleaching signal a useful tool for dosimetry during photodynamic therapy?

Ronald Sroka; H. Heinritz; Peter Heil; M. Ludwig; Jurina M. Wessels

doi:10.1117/12.168683

1 March 1994 Is the photobleaching signal a useful tool for dosimetry during photodynamic therapy?

Ronald Sroka, H. Heinritz, Peter Heil, M. Ludwig, Jurina M. Wessels

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168683
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

Photosensitizing drugs (e.g. porphyrins) are likely to be degraded upon irradiation. The mechanisms of photodegradation are complex. The photodegradation behavior of photosensitizers used in photodynamic therapy (PDT) could be used as a tool for dosimetry and for protecting adjacent tissue against photodynamic effects. The photobleaching behavior of (delta) -aminolevulinic acid induced porphyrins has been studied. The results of in vitro experiments (Protoporphyrin IX in organic solvent) and the in vivo tests (SSK2-fibrosarcoma on C3H-mice) have shown the bleaching rate to be dependent on the environment of the photosensitizer. During its photodegradation a chlorine-type photoproduct is formed. Its spectrometric detection reveals on signals proposed for dosimetry in PDT.

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Ronald Sroka, H. Heinritz, Peter Heil, M. Ludwig, and Jurina M. Wessels "Is the photobleaching signal a useful tool for dosimetry during photodynamic therapy?", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168683

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