Optical diagnostics based on elastic scattering: recent clinical demonstrations with the Los Alamos optical biopsy system

Irving J. Bigio; Thomas R. Loree; Judith R. Mourant; Tsutomu Shimada; K. Story-Held; Randolph D. Glickman; Richard L. Conn

doi:10.1117/12.166823

15 January 1994 Optical diagnostics based on elastic scattering: recent clinical demonstrations with the Los Alamos optical biopsy system

Irving J. Bigio, Thomas R. Loree, Judith R. Mourant, Tsutomu Shimada, K. Story-Held, Randolph D. Glickman, Richard L. Conn

Author Affiliations +

Proceedings Volume 2081, Optical Biopsy; (1994) https://doi.org/10.1117/12.166823
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

A non-invasive diagnostic tool that could identify malignancy in situ and in real time would have a major impact on the detection and treatment of cancer. We have developed and are testing early prototypes of an optical biopsy system (OBS) for detection of cancer and other tissue pathologies. The OBS invokes a unique approach to optical diagnosis of tissue pathologies based on the elastic scattering properties, over a wide range of wavelengths, of the microscopic structure of the tissue. In addition to the reduced invasiveness of this technique compared with current state-of-the-art methods (surgical biopsy and pathology analysis), the OBS offers the possibility of impressively faster diagnostic assessment.

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Irving J. Bigio, Thomas R. Loree, Judith R. Mourant, Tsutomu Shimada, K. Story-Held, Randolph D. Glickman, and Richard L. Conn "Optical diagnostics based on elastic scattering: recent clinical demonstrations with the Los Alamos optical biopsy system", Proc. SPIE 2081, Optical Biopsy, (15 January 1994); https://doi.org/10.1117/12.166823

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