Experimental studies of combination of PDT and tumor chemotherapy or 60Co irradiation

Janina Didziapetriene; Grazina Prasmickiene; Dalija Sukeliene; Ricardas Rotomskis; Giedre Streckyte; Vydmantas Atkocius; Laima Staciokiene; Valerijus Smilgevicius

doi:10.1117/12.199172

12 January 1995 Experimental studies of combination of PDT and tumor chemotherapy or ⁶⁰Co irradiation

Janina Didziapetriene, Grazina Prasmickiene, Dalija Sukeliene, Ricardas Rotomskis, Giedre Streckyte, Vydmantas Atkocius, Laima Staciokiene, Valerijus Smilgevicius

Author Affiliations +

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199172
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

We present experimental results obtained by combining photodynamic therapy (PDT) with tumor chemotherapy or radiotherapy. Dimethoxyhematoporphyrin (DMHp) and photosan (PS) were used as photosensitizers, pharanoxi and vincristine as antitumor drugs. The therapeutic effect of the combination of PDT and antitumor drugs (pharanoxi, vincristine) slightly increases as compared to the treatment of PDT or antitumor drug alone. The additive therapeutic effect is achieved under the combination of PDT and ⁶⁰Co irradiation. It seems that the sensitizers DMHp and PS regulate lipid peroxidation in blood serum of experimental animals, which becomes more active under the influence of alkylating antitumor drugs. Therefore, they could protect an organism from negative influence of tumor chemotherapy.

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Janina Didziapetriene, Grazina Prasmickiene, Dalija Sukeliene, Ricardas Rotomskis, Giedre Streckyte, Vydmantas Atkocius, Laima Staciokiene, and Valerijus Smilgevicius "Experimental studies of combination of PDT and tumor chemotherapy or ⁶⁰Co irradiation", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199172

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