Monte Carlo investigations of elastic scattering spectroscopy applied to latex spheres used as tissue phantoms

James D. Boyer; Judith R. Mourant; Irving J. Bigio

doi:10.1117/12.209958

30 May 1995 Monte Carlo investigations of elastic scattering spectroscopy applied to latex spheres used as tissue phantoms

James D. Boyer, Judith R. Mourant, Irving J. Bigio

Author Affiliations +

Proceedings Volume 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation; (1995) https://doi.org/10.1117/12.209958
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

An optical-fiber-coupled, elastic-scatter spectrometer has proven effective in discriminating between malignant and nonmalignant tissue in the human bladder and gastrointestinal tract. The system injects broadband light into the tissue with an optical fiber and spectrally analyzes the returning light collected by an adjacent fiber. The collected photons have experienced multiple scattering events and therefore arrive at the analysis fiber after traveling varied paths. The diameter of the source fiber is comparable to its separation from the collection fiber. The diffusion model is inappropriate for this geometry; therefore, Monte Carlo simulations are used. In addition, the size of the scattering sites in tissue are expected to be of the same order as the excitation wavelengths, and Mie theory is expected to provide the best description of the scattering and extinction. We will present and compare the results of simulations and measurements of the elastic scatter signal for suspensions of latex spheres in hemoglobin solutions of varying concentrations.

Citation Download Citation

James D. Boyer, Judith R. Mourant, and Irving J. Bigio "Monte Carlo investigations of elastic scattering spectroscopy applied to latex spheres used as tissue phantoms", Proc. SPIE 2389, Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation, (30 May 1995); https://doi.org/10.1117/12.209958

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