Importance of fluence rate in photodynamic therapy with ALA-induced PpIX and BPD-MA in a rat bladder tumor model

Seiichi Iinuma; Georges A. Wagnieres; Kevin T. Schomacker; Mike Bamberg; Tayyaba Hasan

doi:10.1117/12.208182

1 May 1995 Importance of fluence rate in photodynamic therapy with ALA-induced PpIX and BPD-MA in a rat bladder tumor model

Seiichi Iinuma, Georges A. Wagnieres, Kevin T. Schomacker, Mike Bamberg, Tayyaba Hasan

Author Affiliations +

Proceedings Volume 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV; (1995) https://doi.org/10.1117/12.208182
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Oxygen dependent phototoxicity was investigated in vivo in an orthotopic rat bladder tumor model. Two photosensitizers, benzoporphyrin derivative monoacid ring A and 5-aminolevulinic acid-induced protoporphyrin IX were studied. For a given cumulative light dose of 30 J/cm², enhanced tumor destruction was obtained for both photosensitizers by either using a low fluence rate or fractionated light delivery mode. These observations may be attributed to rapid local oxygen consumption during photochemical reactions.

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Seiichi Iinuma, Georges A. Wagnieres, Kevin T. Schomacker, Mike Bamberg, and Tayyaba Hasan "Importance of fluence rate in photodynamic therapy with ALA-induced PpIX and BPD-MA in a rat bladder tumor model", Proc. SPIE 2392, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy IV, (1 May 1995); https://doi.org/10.1117/12.208182

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