5-ALA assisted photodynamic therapy in canine prostates

Ronald Sroka; Rolf Muschter M.D.; Ruth Knuechel; Pia Steinbach; Aaron P. Perlmutter M.D.; Thomas Martin; Reinhold Baumgartner

doi:10.1117/12.240025

17 May 1996 5-ALA-assisted photodynamic therapy in canine prostates

Ronald Sroka, Rolf Muschter M.D., Ruth Knuechel, Pia Steinbach, Aaron P. Perlmutter M.D., Thomas Martin, Reinhold Baumgartner

Author Affiliations +

Proceedings Volume 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI; (1996) https://doi.org/10.1117/12.240025
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) and interstitial thermotherapy are well known treatment modalities in urology. The approach of this study is to combine both to achieve a selective treatment procedure for benign prostatic hyperplasia (BPH) and prostate carcinoma. Measurements of thy in-vivo pharmacokinetics of 5-ALA induced porphyrins by means of fiber assisted ratiofluorometry showed a maximum fluorescence intensity at time intervals of 3 - 4 h post administration. Fluorescence microscopy at that time showed bright fluorescence in epithelial cells while in the stroma fluorescence could not be observed. Interstitial PDT using a 635-nm dye laser with an irradiation of 50 J/cm² resulted in a nonthermic hemorrhagic lesion. The lesion size did not change significantly when an irradiation of 100 J/cm² was used. The usefulness of PDT for treating BPH as well as prostate carcinoma has to be proven in further studies.

Citation Download Citation

Ronald Sroka, Rolf Muschter M.D., Ruth Knuechel, Pia Steinbach, Aaron P. Perlmutter M.D., Thomas Martin, and Reinhold Baumgartner "5-ALA-assisted photodynamic therapy in canine prostates", Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); https://doi.org/10.1117/12.240025

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