Monte Carlo simulations incorporating Mie calculations of light transport in tissue phantoms: examination of photon sampling volumes for endoscopically compatible fiber optic probes

Judith R. Mourant; Andreas H. Hielscher; Irving J. Bigio

doi:10.1117/12.237580

5 April 1996 Monte Carlo simulations incorporating Mie calculations of light transport in tissue phantoms: examination of photon sampling volumes for endoscopically compatible fiber optic probes

Judith R. Mourant, Andreas H. Hielscher, Irving J. Bigio

Author Affiliations +

Proceedings Volume 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy; (1996) https://doi.org/10.1117/12.237580
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Details of the interaction of photons with tissue phantoms are elucidated using Monte Carlo simulations. In particular, photon sampling volumes and photon pathlengths are determined for a variety of scattering and absorption parameters. The Monte Carlo simulations are specifically designed to model light delivery and collection geometries relevant to clinical applications of optical biopsy techniques. The Monte Carlo simulations assume that light is delivered and collected by two, nearly-adjacent optical fibers and take into account the numerical aperture of the fibers as well as reflectance and refraction at interfaces between different media. To determine the validity of the Monte Carlo simulations for modeling the interactions between the photons and the tissue phantom in these geometries, the simulations were compared to measurements of aqueous suspensions of polystyrene microspheres in the wavelength range 450 - 750 nm.

Citation Download Citation

Judith R. Mourant, Andreas H. Hielscher, and Irving J. Bigio "Monte Carlo simulations incorporating Mie calculations of light transport in tissue phantoms: examination of photon sampling volumes for endoscopically compatible fiber optic probes", Proc. SPIE 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy, (5 April 1996); https://doi.org/10.1117/12.237580

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