Optical spectroscopy of benign and malignant breast tissues

Yuanlong Yang; Alvin Katz; Edward J. Celmer M.D.; Margaret Zurawska-Szczepaniak; Robert R. Alfano

doi:10.1117/12.237597

5 April 1996 Optical spectroscopy of benign and malignant breast tissues

Yuanlong Yang, Alvin Katz, Edward J. Celmer M.D., Margaret Zurawska-Szczepaniak, Robert R. Alfano

Proceedings Volume 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy; (1996) https://doi.org/10.1117/12.237597
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

Fluorescence spectroscopy was applied to characterize normal, malignant and adipose breast tissues. Excitation, emission, and synchronized diffusive reflectance spectral scans were measured on over one hundred specimens for the purpose of developing an improved spectroscopic diagnostic technique. These techniques were able to successfully distinguish malignant tissue from adipose glandular fibrous and normal tissue. A sensitivity of 91% for fifty-six (56) malignant specimens with specificity of 91% for forty-six (46) benign tissue specimens has been achieved, using pathology as the golden standard.

Citation Download Citation

Yuanlong Yang, Alvin Katz, Edward J. Celmer M.D., Margaret Zurawska-Szczepaniak, and Robert R. Alfano "Optical spectroscopy of benign and malignant breast tissues", Proc. SPIE 2679, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases III: Optical Biopsy, (5 April 1996); https://doi.org/10.1117/12.237597

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