Perfluorocarbon compounds: transmitting liquids for infrared laser tissue ablation

Martin Frenz; Hans Surya Pratisto; Cynthia A. Toth M.D.; E. Duco Jansen; Hans Joerg Altermatt; Ashley J. Welch; Heinz P. Weber

doi:10.1117/12.239593

7 May 1996 Perfluorocarbon compounds: transmitting liquids for infrared laser tissue ablation

Martin Frenz, Hans Surya Pratisto, Cynthia A. Toth M.D., E. Duco Jansen, Hans Joerg Altermatt, Ashley J. Welch, Heinz P. Weber

Author Affiliations +

Proceedings Volume 2681, Laser-Tissue Interaction VII; (1996) https://doi.org/10.1117/12.239593
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

One concern during IR-laser ablation of tissue under water is the mechanical injury that may be induced in tissue due to rapid bubble expansion and collapse or due to strong laser-induced pressure waves. The objective of this study was to evaluate the feasibility of using a liquid which is transparent to the IR-region of the spectrum in order to minimize these undesired mechanical side-effects. As transmitting medium perfluorocarbon liquid was used. Free- running Er:YAG and Ho:YAG laser pulses were delivered into the liquid via a 400 micrometers fiber. Bubble formation during the ablation process was recorded with fast flash photography while pressure transients were measured with a needle hydrophone. The effect of the surrounding material (air, water, perfluorooctane) on the tissue response of chicken breast was evaluated in vitro using histology. It was observed that a large bubble (up to 6 mm in diameter) was formed under perfluorooctane driven by the ablation products. This bubble, however, does not generate a pressure wave when collapsing. Although perfluorooctane only shows a weak absorption for infrared radiation, laser-induced thermal lensing in the liquid strongly decreases the radiant exposure and therefore the ablation efficiency.

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Martin Frenz, Hans Surya Pratisto, Cynthia A. Toth M.D., E. Duco Jansen, Hans Joerg Altermatt, Ashley J. Welch, and Heinz P. Weber "Perfluorocarbon compounds: transmitting liquids for infrared laser tissue ablation", Proc. SPIE 2681, Laser-Tissue Interaction VII, (7 May 1996); https://doi.org/10.1117/12.239593

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