Measurement of the light dosimetry parameters in PDT: definition of a dedicated instrumentation

F. Jaffry; V. Louis; Yves Granjon; Francois H. Guillemin; Edouard Yvroud

doi:10.1117/12.273500

8 May 1997 Measurement of the light dosimetry parameters in PDT: definition of a dedicated instrumentation

F. Jaffry, V. Louis, Yves Granjon, Francois H. Guillemin, Edouard Yvroud

Proceedings Volume 2972, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VI; (1997) https://doi.org/10.1117/12.273500
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

The PDT uses the LASER characteristics in order to treat locally some types of cancers.Its principle is to irradiate the tumoral zones after the injection of a photosensitizer. Two processes take place during the treatment: one of them is a photochemical process and the other is a photothermal one. The parameters of major interest involved in these processes are the light energy, the oxygen rate in the tumor and the temperature. the aim of the light dosimetry is to optimize the light dose delivered by the LASER in order to enhance the therapeutic yield of the treatment. A sensor dedicated to this task has been studied in our laboratory. Our aim is to perform the measurement of several light dosimetry parameters with a single sensor. These parameters are the light attenuation coefficient, the oxygen saturation and the temperature. The general principle of the instrumentation is based on the backscattering of the light emitted by the optical treatment fiber. The associated instrumentation is composed with three parts: an optical structure, an electronic system and a software for the digital treatment. Our goal is to use this sensor in order to define a general method to extract the different parameters from the single backscattered signal.

Citation Download Citation

F. Jaffry, V. Louis, Yves Granjon, Francois H. Guillemin, and Edouard Yvroud "Measurement of the light dosimetry parameters in PDT: definition of a dedicated instrumentation", Proc. SPIE 2972, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy VI, (8 May 1997); https://doi.org/10.1117/12.273500

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KEYWORDS

Tissues

Oxygen

Resistors

Sensors

Tumors

Photodynamic therapy

Optical testing

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