Spectral-selective fluorescence imaging for diagnostics of surface cancer

Alexander V. Vinogradov; Alexey I. Trushin; Pavel G. Leonov; Michael L. Stahanov

doi:10.1117/12.307338

10 April 1998 Spectral-selective fluorescence imaging for diagnostics of surface cancer

Alexander V. Vinogradov, Alexey I. Trushin, Pavel G. Leonov, Michael L. Stahanov

Proceedings Volume 3259, Systems and Technologies for Clinical Diagnostics and Drug Discovery; (1998) https://doi.org/10.1117/12.307338
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

We report on porphyrin autofluorescence imaging diagnostic of surface cancer. Digital computer fluorescent methods get real time, non-invasive, in vivo cancer diagnostic. Output information has clear picture form. Results may be placed in imaging data bases and sent via computer networks. We received our laboratory results without exogenous porphyrins or pharmaceutical stimulation of endogenous porphyrin production. The results were confirmed by histological tests. Autofluorescence was exited via He-Ne laser. Extra sensitive digital TV system was used for image capturing. Image was grabbed in the narrow spectral fluorescence band about 680 nm. The fluorescent image delivered quantity information on the porphyrin spatial distribution. Bright spots on the image were cancer suspected places. We combined usual color image with the fluorescent image and marked suspected places. Then these places were tested by standard diagnostic methods. Combination of image fluorescent and standard methods allowed us to find out invisible or very small cancer lesions. In our report we discuss the relation between traditional laser induced fluorescent spectroscopy diagnostic and fluorescent imaging. In our opinion the method is especially efficient at early disease stages, when lesion is very compact and clinical picture is not clear.

Citation Download Citation

Alexander V. Vinogradov, Alexey I. Trushin, Pavel G. Leonov, and Michael L. Stahanov "Spectral-selective fluorescence imaging for diagnostics of surface cancer", Proc. SPIE 3259, Systems and Technologies for Clinical Diagnostics and Drug Discovery, (10 April 1998); https://doi.org/10.1117/12.307338

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
6 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Cancer

Diagnostics

Luminescence

Skin

Laser induced fluorescence

Tumors

Skin cancer

Show All Keywords

Keywords/Phrases

Search In:

Publication Years