Remote sensing as a method of cervical cancer diagnosis

Alex R. Zelenchuk; Mark D. Modell; Louis Burke M.D.; J. Niloff; Roman Karlinskiy; Y. Resnichenko; Nataliya A. Shestopal

doi:10.1117/12.310561

9 June 1998 Remote sensing as a method of cervical cancer diagnosis

Alex R. Zelenchuk, Mark D. Modell, Louis Burke M.D., J. Niloff, Roman Karlinskiy, Y. Resnichenko, Nataliya A. Shestopal

Proceedings Volume 3261, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing V; (1998) https://doi.org/10.1117/12.310561
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

Laser induced fluorescence is widely being developed as a new method for early detection of pre-cancerous tissue. Typically an optical fiber probe directly contacting tissue is used for detection and localization of abnormal tissue. This method of tissue interrogation has certain clinical and diagnostic restrictions due to physical contact with the tissue. This method of tissue interrogation has certain clinical and diagnostic restrictions due to physical contact with the tissue. The objective of our study was to investigate the method of remote sensing in colposcopy. The device was designed using an optical multichannel analyzer with UV excitation. The excitation light is delivered through the fiber bundle to the optical head that is attached to the colposcope. This arrangement allows one to conveniently collect fluorescence spectra from the cervix during regular colposcopy examination. To understand the practical restrictions of the remote sensing the influence of various factors are studied. A few modifications of the device were tested. Phantoms were created and used to test the device. Data form more than 200 patients shows substantial improvement in sensitivity and specificity compared with the doctor's impressions. The result of the experimental measurements of tissue-like phantoms and in- vivo measurements are provided. The modification increased the average signal/noise ration more than 4 times.

Citation Download Citation

Alex R. Zelenchuk, Mark D. Modell, Louis Burke M.D., J. Niloff, Roman Karlinskiy, Y. Resnichenko, and Nataliya A. Shestopal "Remote sensing as a method of cervical cancer diagnosis", Proc. SPIE 3261, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing V, (9 June 1998); https://doi.org/10.1117/12.310561

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available