Glucose determination with fiber optic spectrometers

Eva Starke; Ulf Kemper; Dieter Barschdorff

doi:10.1117/12.348381

17 May 1999 Glucose determination with fiber optic spectrometers

Eva Starke, Ulf Kemper, Dieter Barschdorff

Proceedings Volume 3599, Optical Diagnostics of Biological Fluids IV; (1999) https://doi.org/10.1117/12.348381
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Noninvasive blood glucose monitoring is the aim of research activities concerning the detection of small glucose concentrations dissolved in water and blood plasma. One approach for these measurements is the exploitation of absorption bands in the near infrared. However, the strong absorption of water represents a major difficulty. Transmission measurements of glucose dissolved in water and in blood plasma in the spectral region around 1600 nm with one- beam spectrometers and a FT-IR spectrometer are discussed. The evaluation of the data is carried out using a two-layer Lambert-Beer model and neural networks. In order to reduce the dimensions of a potential measuring device, an integrated acousto-optic tunable filter (AOTF) with an Erbium doped fiber amplifier as a radiation source is used. The fiber optic components are examined concerning their suitability. The smallest concentrations of glucose dissolved in water that can be separated are approximately 50 mg/dl. In the range of 50 mg/dl to 1000 mg/dl a correlation coefficient of 0.98 between real and estimated glucose concentrations is achieved using neural networks. In blood plasma so far glucose concentrations of about 100 mg/dl can be distinguished with good accuracy.

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Eva Starke, Ulf Kemper, and Dieter Barschdorff "Glucose determination with fiber optic spectrometers", Proc. SPIE 3599, Optical Diagnostics of Biological Fluids IV, (17 May 1999); https://doi.org/10.1117/12.348381

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KEYWORDS

Glucose

Plasma

Absorption

Blood

Spectrometers

Absorbance

Fiber optics

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