In-vivo Raman spectroscopy of human skin: determination of the composition of natural moisturizing factor

Peter J. Caspers; Gerald W. Lucassen; Rolf Wolthuis; Hajo A. Bruining; Gerwin J. Puppels

doi:10.1117/12.345389

9 April 1999 In-vivo Raman spectroscopy of human skin: determination of the composition of natural moisturizing factor

Peter J. Caspers, Gerald W. Lucassen, Rolf Wolthuis, Hajo A. Bruining, Gerwin J. Puppels

Proceedings Volume 3608, Biomedical Applications of Raman Spectroscopy; (1999) https://doi.org/10.1117/12.345389
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Near IR confocal Raman spectroscopy is a non-invasive and non-destructive technique that can provide information about molecular structure and composition in vivo. It is therefore of great interest for skin research. Neither samples preparation nor the use of markers and dyes are required. High quality spectra of the skin can be obtained in several seconds to minutes. Here we present in vivo Raman spectra of the outermost skin layer: stratum corneum. The spectra are interpreted in terms of differences between the molecular composition of the stratum corneum at two different body locations.

Citation Download Citation

Peter J. Caspers, Gerald W. Lucassen, Rolf Wolthuis, Hajo A. Bruining, and Gerwin J. Puppels "In-vivo Raman spectroscopy of human skin: determination of the composition of natural moisturizing factor", Proc. SPIE 3608, Biomedical Applications of Raman Spectroscopy, (9 April 1999); https://doi.org/10.1117/12.345389

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