Phototoxic properties of dibiotinylated aluminum sulphophthalocyanine in vitro and in vivo

Irina G. Meerovich; Victoria V. Zherdeva; Eugeny A. Lukianets; Valentina M. Derkacheva; Georgy N. Vorozhtsov; Gennadii A. Meerovich; Eugenia A. Kogan; Alexander P. Savitsky

doi:10.1117/12.413716

31 January 2001 Phototoxic properties of dibiotinylated aluminum sulphophthalocyanine in vitro and in vivo

Irina G. Meerovich, Victoria V. Zherdeva, Eugeny A. Lukianets, Valentina M. Derkacheva, Georgy N. Vorozhtsov, Gennadii A. Meerovich, Eugenia A. Kogan, Alexander P. Savitsky

Author Affiliations +

Proceedings Volume 4156, Clinical Lasers and Diagnostics; (2001) https://doi.org/10.1117/12.413716
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

The investigations of photodynamic activity of the dibiotinylated aluminium sulphophthalocyanine in vitro and in vivo were performed. The results obtained showed that in vitro dibiotinylated aluminium sulphophthalocyanine provides an effective damage of small cell lung carcinoma OAT-75. In vivo dibiotinylated aluminium sulphophthalocyanine induces a total damage of Erlich carcinoma with expressed vascular damage even in a concentration 0.5 mg/kg of body weight.

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Irina G. Meerovich, Victoria V. Zherdeva, Eugeny A. Lukianets, Valentina M. Derkacheva, Georgy N. Vorozhtsov, Gennadii A. Meerovich, Eugenia A. Kogan, and Alexander P. Savitsky "Phototoxic properties of dibiotinylated aluminum sulphophthalocyanine in vitro and in vivo", Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); https://doi.org/10.1117/12.413716

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