Change of optical properties of the breast tissues under the influence of pharmacological agents

Sergey A. Naumov; Sergey M. Vovk; Sergey V. Pushkarev; Vitaly A. Volovodenko

doi:10.1117/12.427837

21 May 2001 Change of optical properties of the breast tissues under the influence of pharmacological agents

Sergey A. Naumov, Sergey M. Vovk, Sergey V. Pushkarev, Vitaly A. Volovodenko

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427837
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The influence of vasoactive pharmacological agents (VPhA) on the spectral characteristics of the breast tissues in vivo has been studied. The effect of adrenaline and its antagonist dibazole on the character of diffuse reflection spectra of the breast registered during puncture biopsy were investigated. Adrenaline and dibazole were injected both locally, i.e. to the examined breast tissue and subcutaneously to the shoulder. The choice of this or that VPhA was caused by the functional condition of an examinee. It has been shown that the main functional units of the stroma of parenchymatous organs and their tumors responsible for the state of spectral characteristics in vivo are considered to be the vessels. The cancerous tissue has a lesser pronounced response compared to the normal one that is indicative of the functional inferiority of the tumor vessels and it is confirmed by the results of morphological examinations including the ultrastructural level. Thus, using VPhA it is possible to have an influence on characteristics of diffuse reflection spectra of the examined tissues in vivo and make diagnostics more effectively.

Citation Download Citation

Sergey A. Naumov, Sergey M. Vovk, Sergey V. Pushkarev, and Vitaly A. Volovodenko "Change of optical properties of the breast tissues under the influence of pharmacological agents", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427837

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KEYWORDS

Tissues

Breast

Tumors

Diagnostics

In vivo imaging

Tissue optics

Biopsy

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