Preliminary study of near-infrared tomographic imaging of heterogeneous media: simulations and images of excised breast tissue

Troy O. McBride; Brian W. Pogue; Wendy A. Wells; Shudong Jiang; Ulf L. Oesterberg; Keith D. Paulsen

doi:10.1117/12.434491

29 June 2001 Preliminary study of near-infrared tomographic imaging of heterogeneous media: simulations and images of excised breast tissue

Troy O. McBride, Brian W. Pogue, Wendy A. Wells, Shudong Jiang, Ulf L. Oesterberg, Keith D. Paulsen

Author Affiliations +

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434491
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

A preliminary study of the effect of a spatially heterogeneous background upon near-infrared tomographic imaging is presented using computer simulations and phantom experiments. In simulations, increasing heterogeneity is added to a sample region and the reconstructed images are analyzed. A finite-element reconstruction algorithm based on the frequency-domain diffusion equation is used. A phantom study for a heterogeneous object was performed by embedding an object in excised breast tissue. The ability to distinguish and quantify a heterogeneous inclusion in a heterogeneous background is discussed. In this case, a 20 mm diameter object in a 100 mm background is characterized with up to 75% added heterogeneity in simulation. A 30 mm cube of pork embedded in a 86 mm sample of excised breast tissue is localized and recovered to within 25% of its expected contrast.

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Troy O. McBride, Brian W. Pogue, Wendy A. Wells, Shudong Jiang, Ulf L. Oesterberg, and Keith D. Paulsen "Preliminary study of near-infrared tomographic imaging of heterogeneous media: simulations and images of excised breast tissue", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434491

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