Optical biopsy for the diagnosis of dysplasia in Barrett's oesophagus

David C. O. Pickard; Irving J. Bigio; Stephen G. Bown; Laurence B. Lovat; Paul M. Ripley; Marco Novelli

doi:10.1117/12.447133

31 October 2001 Optical biopsy for the diagnosis of dysplasia in Barrett's oesophagus

David C. O. Pickard, Irving J. Bigio, Stephen G. Bown, Laurence B. Lovat, Paul M. Ripley, Marco Novelli

Proceedings Volume 4432, Diagnostic Optical Spectroscopy in Biomedicine; (2001) https://doi.org/10.1117/12.447133
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

Barrett's oesophagus is an increasingly common pre-cancerous condition, which occurs in patients suffering from acid reflux into their gullet. Biopsies must be taken from patients diagnosed with this condition regularly to pick up signs of pre-cancerous changes. Elastic scattering spectroscopy offers the possibility of distinguishing between benign and pre-cancerous changes in the lower oesophagus with a relatively simple optical measurement. This optical biopsy is correlated with a conventional histopathological specimen obtained at the same point. It is shown that to a relatively high degree of sensitivity and specificity it is possible to distinguish between pre-malignant patches, benign lesions and normal tissue.

Citation Download Citation

David C. O. Pickard, Irving J. Bigio, Stephen G. Bown, Laurence B. Lovat, Paul M. Ripley, and Marco Novelli "Optical biopsy for the diagnosis of dysplasia in Barrett's oesophagus", Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); https://doi.org/10.1117/12.447133

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