Fluorescence spectroscopic analysis (FSA) detects quantitative changes in atherosclerotic plaque collagen and elastin content In Vivo

Alexander M. Christov; Erbin Dai M.D.; Liying Liu; Haiyan Guan; Mark A. Bernards; Paul B. Cavers; David Susko; Alexandra Lucas

doi:10.1117/12.465232

1 May 2002 Fluorescence spectroscopic analysis (FSA) detects quantitative changes in atherosclerotic plaque collagen and elastin content In Vivo

Alexander M. Christov, Erbin Dai M.D., Liying Liu, Haiyan Guan, Mark A. Bernards, Paul B. Cavers, David Susko, Alexandra Lucas

Author Affiliations +

Proceedings Volume 4613, Optical Biopsy IV; (2002) https://doi.org/10.1117/12.465232
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

In order to assess the capacity for in vivo fluorescence spectroscopi8c analysis of arterial collagen and elastin, fluorescence emission intensity was recorded form rabbit aorta after angioplasty and stent implant, and correlated with extracted elastin and collagen content. FEI from saline treated rabbits after stent implant was higher between 485 and 500 nm than after anti-inflammatory treatment. FEI was significantly decreased after implantation of shorter stents at 476-500 nm. Multiple regression analysis demonstrated an excellent correlation between FEI and elastin and HPLC- measured collagen content at 486-500 nm and 476-480 nm respectively. Conclusions: FEI recorded in vivo form arterial intimal surface, can be successfully used for quantitative assessment of compositional changes in connective tissue. Stent implant can induce changes in intimal arterial structure at discrete sites distant from the stent implant site.

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Alexander M. Christov, Erbin Dai M.D., Liying Liu, Haiyan Guan, Mark A. Bernards, Paul B. Cavers, David Susko, and Alexandra Lucas "Fluorescence spectroscopic analysis (FSA) detects quantitative changes in atherosclerotic plaque collagen and elastin content In Vivo", Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); https://doi.org/10.1117/12.465232

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