Optimizing optical imaging of tumor-like inclusions in biological tissues

Vladimir V. Barun; Alphiya Ya. Khairullina

doi:10.1117/12.468907

30 May 2002 Optimizing optical imaging of tumor-like inclusions in biological tissues

Vladimir V. Barun, Alphiya Ya. Khairullina

Proceedings Volume 4749, ICONO 2001: Novel Trends in Nonlinear Laser Spectroscopy and Optical Diagnostics and Lasers in Chemistry, Biophysics, and Biomedicine; (2002) https://doi.org/10.1117/12.468907
Event: XVII International Conference on Coherent and Nonlinear Optics (ICONO 2001), 2001, Minsk, Belarus

Abstract

We use the diffusion approximation to the radiative transfer equation and the respective analytical relations to theoretically treat the imaging of phantom biological tissue with an inclusion under external illumination. The horizontal inhomogeneity of the scattering and absorbing tissue medium owing to the includion is taken into account. Several measuring setups are computationally considered to investigate their advantages and drawbacks under the sounding of inclusions by reflected and transmitted light. We varied the absolute and respective values of the absorption coefficients of the inclusion and surrounding tissue to illustrate the imaging of 'clear' and 'dark' inclusions through the turbid medium. The comparison is made with the so-called base scheme when an arrow laser bam illuminates the medium and narrow-angle receiver records reflected radiation at some distance or base from the light source. A simple formula to calculate the image contrast of a small inclusion with the contrast observed. We illustrate the computations by experimental spectral absorption and extinction curves to enable one an opportunity to estimate some advantages while searching and changing the operational range of wavelengths utilized to sound a tumor inside normal tissue.

Citation Download Citation

Vladimir V. Barun and Alphiya Ya. Khairullina "Optimizing optical imaging of tumor-like inclusions in biological tissues", Proc. SPIE 4749, ICONO 2001: Novel Trends in Nonlinear Laser Spectroscopy and Optical Diagnostics and Lasers in Chemistry, Biophysics, and Biomedicine, (30 May 2002); https://doi.org/10.1117/12.468907

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KEYWORDS

Tissues

Absorption

Tissue optics

Protactinium

Light scattering

Scattering

Tumors

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