In vivo local determination of tissue optical properties: instrumentation and application

Wei Zhang; Hui Gong; Guiling Wu; Pengcheng Li; Qingming Luo

doi:10.1117/12.476138

22 July 2003 In vivo local determination of tissue optical properties: instrumentation and application

Wei Zhang, Hui Gong, Guiling Wu, Pengcheng Li, Qingming Luo

Proceedings Volume 4958, Advanced Biomedical and Clinical Diagnostic Systems; (2003) https://doi.org/10.1117/12.476138
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

We have developed an optical probe for local determination of tissue optical properties using a small source-detector separation (<1mm). A 1310nm LED (25 μW) coupled to a fiber with 62.5 μm diameter was used as the light source and multiple detector fibers were employed to achieve spatially resolved reflectance measurement. Each detector fiber has a diameter of 62.5 μm and apart away 125 μm from each other. Pin detectors and continuous wave detection scheme were performed to obtain a sensitivity of 4x10⁹V/W and 82dB dynamic range. Applied to the normal human skin in the forearm, 63dB signal to noise ration can be achieved with a time resolution less than 1 second. The absorption and scattering coefficientions of tissue can be calculated by generalized diffusion approximation with measured reflective intensity. In this paper, we discussed the design of the system in general, and then described our instrument, along with the technique issues that influenced its design. Phantom experimental was performed to analyze the relationship between the reflectance light and the optical properties (μ_a, μ_s). The results showed that this optical probe could be used for local determination of tissue optical properties.

Citation Download Citation

Wei Zhang, Hui Gong, Guiling Wu, Pengcheng Li, and Qingming Luo "In vivo local determination of tissue optical properties: instrumentation and application", Proc. SPIE 4958, Advanced Biomedical and Clinical Diagnostic Systems, (22 July 2003); https://doi.org/10.1117/12.476138

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available