Cell differentiation based on the interference pattern between the incident and scattered light: a numerical study

Caigen Liu; Clarence E. Capjack; Wojciech Rozmus

doi:10.1117/12.529121

1 July 2004 Cell differentiation based on the interference pattern between the incident and scattered light: a numerical study

Caigen Liu, Clarence E. Capjack, Wojciech Rozmus

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Proceedings Volume 5319, Laser Interaction with Tissue and Cells XV; (2004) https://doi.org/10.1117/12.529121
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

We present a new interference pattern based scheme for the cell diagnostics. In this approach the biological cell is illuminated by a spherical light source. The interference pattern that is created by the unscattered incident light and the light that is scattered by a cell is used for cell diagnostics. A three-dimensional computational code (AETHER) for solving the full set of Maxwell’s equations with the Finite-Difference Time-Domain (FDTD) method has been used to numerically determine the interference light intensity pattern between the unscattered incident light and the scattered light. Features of the interference patterns that are obtained for different cellular parameters and structures are discussed. We have numerically shown that the interference intensity pattern can replace the purely scattered light patterns currently used in cell diagnostics.

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Caigen Liu, Clarence E. Capjack, and Wojciech Rozmus "Cell differentiation based on the interference pattern between the incident and scattered light: a numerical study", Proc. SPIE 5319, Laser Interaction with Tissue and Cells XV, (1 July 2004); https://doi.org/10.1117/12.529121

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KEYWORDS

Light scattering

Diagnostics

Optical testing

Finite-difference time-domain method

Scattering

Spherical lenses

Holography

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