Raman, mid, and NIR FTIR absorption spectra of breast cancer reveal a good diagnosis tool

Yehia A. Badr; Salah Eldin I. HassabElnaby

doi:10.1117/12.523374

18 June 2004 Raman, mid, and NIR FTIR absorption spectra of breast cancer reveal a good diagnosis tool

Yehia A. Badr, Salah Eldin I. HassabElnaby

Proceedings Volume 5325, Optical Diagnostics and Sensing IV; (2004) https://doi.org/10.1117/12.523374
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Fourier transform Raman and IR spectra are examined for malignant and normal breast tissues. Aside from individual differences that result in normal variations in lipids and glycogen, a clear distinction between normal and malignant tissues can be observed. MIR absorption spectra was observed using FTIR-Raman Spectrometer technique working in the regions Mir, Nir, Fir as well as VIS. Also the system can record Raman Scattering in the region from -2000 to 5600 cm-1 using Nd-Yag laser source of power 1500 mW. The comparison of Mid FTIR spectra from different samples of breast tumors with normal spectra reveals very important features that can be usefulk as diagnostic techniques. An absorption line centered at 3303 cm^-1 varies considerably and depends on the nature of the lesion, lipids and proteins composition. The ratio (I₃₄₄₃/I₄₃₅₂) has an average value of 2.4±0.3 for normal tissues while in the case of malignant tissues its average is 4.5±2.8. A broad absorption band was observed in some malignant cases between 2800-3750 cm^-1. A good shaped lines at 4259 and 4332 cm^-1 is clear in normal spectra, these lines tend to disappear in malignant cases. A normally existing line at 3470 cm^-1 increases considerably in malignant cases. When the tumor is not yet malignant it seems that the lines at 4259 and 4320 cm^-1 disappears first rapidly. As the tumor turns to be malignant, the band at 3470 cm^-1 increases and a new well defined band at 5167 cm^-1 appears. Moreover, Raman spectra showed the appearance of a new band at 2900 cm^-1 in the case of malignancy. While in normal breast samples this band didn't show up. Datat obtained in the NIR region confirms our observation in the MIR region.

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Yehia A. Badr and Salah Eldin I. HassabElnaby "Raman, mid, and NIR FTIR absorption spectra of breast cancer reveal a good diagnosis tool", Proc. SPIE 5325, Optical Diagnostics and Sensing IV, (18 June 2004); https://doi.org/10.1117/12.523374

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KEYWORDS

Tissues

Raman spectroscopy

Cancer

Absorption

FT-IR spectroscopy

Tumors

Breast

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