Plasmonic tunable glucose sensing based on the dissociation of Con A-aggregated dextran-coated gold colloids

Chris D. Geddes; Kadir Aslan; Jian Zhang; Joseph R. Lakowicz

doi:10.1117/12.530156

16 June 2004 Plasmonic tunable glucose sensing based on the dissociation of Con A-aggregated dextran-coated gold colloids

Chris D. Geddes, Kadir Aslan, Jian Zhang, Joseph R. Lakowicz

Author Affiliations +

Proceedings Volume 5327, Plasmonics in Biology and Medicine; (2004) https://doi.org/10.1117/12.530156
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

We have recently developed a new approach to glucose sensing based on the aggregation of nanometer-sized noble-metal nanoparticles and their respective change in plasmon absorption upon glucose addition. High molecular weight Dextran coated nanoparticles are aggregated with Concanavalin A, (Con A), where the aggregation results in a significant shift in metal-plasmon absorption. The addition of glucose competitively binds to Con A, reducing nanoparticle aggregation, and therefore the plasmon absorption when monitored at 650 nm. We have optimized our plasmonic glucose sensing mechanism with regard to nanoparticle stability, the dynamic range for glucose sensing and the wavelength of observation, to be compatible with both clinical glucose requirements and measurements.

Citation Download Citation

Chris D. Geddes, Kadir Aslan, Jian Zhang, and Joseph R. Lakowicz "Plasmonic tunable glucose sensing based on the dissociation of Con A-aggregated dextran-coated gold colloids", Proc. SPIE 5327, Plasmonics in Biology and Medicine, (16 June 2004); https://doi.org/10.1117/12.530156

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