Numerical simulation and experimental study on optothermal response of multilayer biological tissue under pulse laser irradiation

Hongqin Yang; Shusen Xie; Zukang Lu

doi:10.1117/12.575226

18 January 2005 Numerical simulation and experimental study on optothermal response of multilayer biological tissue under pulse laser irradiation

Hongqin Yang, Shusen Xie, Zukang Lu

Author Affiliations +

Proceedings Volume 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II; (2005) https://doi.org/10.1117/12.575226
Event: Photonics Asia, 2004, Beijing, China

Abstract

In this study, a novel multilayer-tissue heat transfer model for laser-induced optothermal response is presented by considering the heterogeneous properties of biological tissue. Various temperature measurement techniques for biological tissue under laser irradiation are reviewed. The advantages and limitations of each of these methods are discussed. Based on this, the experimental measurement schemes with a multiple-channel temperature probe for the optical-thermal response of mammalian skin tissue in vitro and in vivo are presented during pulse Er:YAG laser and superpulse CO₂ irradiation. The effect of laser parameters, such as energy density, pulse duration and pulse repetition rate is investigated. Using finite difference method (FDM), the simulation of spatial and temporal distribution of the temperature field inside the biological tissue is investigated during and after pulse laser radiation. Experimental data are fitted and compared to the optical-thermal simulation to test the validation of the model. In addition, the impact factors and uncertainty of the measurement results are discussed. The results we had in this study can be used to predict the temperature rise inside biological tissue under pulse laser irradiation, it is a useful tool for a surgeon to optimize laser parameters before making a therapy plan. It also can predict a temperature rise or thermal damage in interstitial laser thermotherapy.

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Hongqin Yang, Shusen Xie, and Zukang Lu "Numerical simulation and experimental study on optothermal response of multilayer biological tissue under pulse laser irradiation", Proc. SPIE 5630, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, (18 January 2005); https://doi.org/10.1117/12.575226

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