Ultrahigh resolution optical coherence tomography of human skin

B. Povazay; A. Unterhuber; B. Hermann; S. Gasparoni; H. Kittler; H. Sattmann; F. Roka; M. Binder; K. Bizheva; R. Leitgeb; H. Pehamberger; W. Drexler

doi:10.1117/12.632985

7 October 2005 Ultrahigh resolution optical coherence tomography of human skin

B. Povazay, A. Unterhuber, B. Hermann, S. Gasparoni, H. Kittler, H. Sattmann, F. Roka, M. Binder, K. Bizheva, R. Leitgeb, H. Pehamberger, W. Drexler

Author Affiliations +

Proceedings Volume 5861, Optical Coherence Tomography and Coherence Techniques II; 58610R (2005) https://doi.org/10.1117/12.632985
Event: European Conferences on Biomedical Optics 2005, 2005, Munich, Germany

Abstract

Ultrahigh resolution OCT (UHR OCT) was performed on normal and pathologic human skin biopsies using an ultrabroad-bandwidth (260 nm) Titanium:sapphire laser, enabling sub-micrometer (0.9 μm) axial UHR OCT resolution. Penetration, image contrast as well as resolution capabilities achieved are analyzed for optimum UHR OCT in vivo performance. With the achieved resolution and the penetration depth, the transition between the dermis and the epidermis is clearly visible by UHR OCT, and also the anomalies of pathologies, which have been confirmed performing a comparison with histological analysis. Three dimensional UHR OCT of normal skin is demonstrated with less than 3 μm axial resolution at video-rate with up to 50 B-scans/second, each tomogram consisting of 512×1024 pixels, resulting in 25 Megavoxels/second.

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B. Povazay, A. Unterhuber, B. Hermann, S. Gasparoni, H. Kittler, H. Sattmann, F. Roka, M. Binder, K. Bizheva, R. Leitgeb, H. Pehamberger, and W. Drexler "Ultrahigh resolution optical coherence tomography of human skin", Proc. SPIE 5861, Optical Coherence Tomography and Coherence Techniques II, 58610R (7 October 2005); https://doi.org/10.1117/12.632985

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