Biomolecules as nanomaterials: interface characterization for sensor development

Gregory Goddard; Jennifer E. Whittier

doi:10.1117/12.658771

31 March 2006 Biomolecules as nanomaterials: interface characterization for sensor development

Proceedings Volume 6172, Smart Structures and Materials 2006: Smart Electronics, MEMS, BioMEMS, and Nanotechnology; 617206 (2006) https://doi.org/10.1117/12.658771
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2006, San Diego, California, United States

Abstract

Extensive research is underway to understand and exploit the interface between biological materials and integrated systems Today, "nanotechnology" can be defined as a group of emerging technologies in which the structure of matter is controlled at the nanometer scale, the scale of small numbers of atoms, to produce novel materials and devices having useful and unique properties. An ideal biological candidate for use in nanoscale devices is the microtubule, an essential component of the eukaryotic cytoskeleton, which, unlike most proteins, has been shown to be electrically conductive. Due to the presence of an intrinsic dipole in the protein polymer, RF reflectance spectroscopy was chosen as an interrogation method. RF reflectance spectroscopy measures the electrical response of a sample in response to sinusoidally alternating currents as a function of frequency By interrogating the protein electrically, we are able to detect the polymerization state of the system, track any associated conductivity changes, and monitor binding of microtubule-associated proteins. We demonstrate manipulation of the microtubule system through the use of low-frequency electric fields, and discuss implications for sensor development.

Citation Download Citation

Gregory Goddard and Jennifer E. Whittier "Biomolecules as nanomaterials: interface characterization for sensor development", Proc. SPIE 6172, Smart Structures and Materials 2006: Smart Electronics, MEMS, BioMEMS, and Nanotechnology, 617206 (31 March 2006); https://doi.org/10.1117/12.658771

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available