In vivo optical characterization of pediatric epileptogenic lesions

W.-C. Lin; J. Ragheb; S. Bhatia; Mahlon D. Johnson; D. Sandberg; A. Fernandez; G. Morrison; M. Duchowny; P. Jayakar

doi:10.1117/12.700717

23 March 2007 In vivo optical characterization of pediatric epileptogenic lesions

W.-C. Lin, J. Ragheb, S. Bhatia, Mahlon D. Johnson, D. Sandberg, A. Fernandez, G. Morrison, M. Duchowny, P. Jayakar

Proceedings Volume 6424, Photonic Therapeutics and Diagnostics III; 642427 (2007) https://doi.org/10.1117/12.700717
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Epileptogenic lesions and their margins are often difficult to define intraoperatively. We hypothesize that optical spectroscopy can detect unique pathophysiological features of epileptogenic lesions in children and hence differentiate them from normal brain. This hypothesis was tested by comparing the in vivo optical and fluorescence characteristics of epileptogenic brain lesions (non-neoplastic) with those of normal brain. Patients were recruited from those receiving epilepsy surgeries at Miami Children's Hospital. Using a portable spectroscopic system, optical characterization of brain was performed intraoperatively. Fluorescence spectra were measured at 337 nm excitation, and diffuse reflectance spectra were measured between 400 and 850 nm. To date, seven epilepsy patients have been enrolled in the study. A couple interesting trends have been observed in the recorded optical spectra. First, sites within the resection zone, as defined by the intracranial electroencephalogram data, often show higher diffuse reflectance signals than normal sites do. This is especially prominent around 500 nm and between 650 and 850 nm. Secondly, several investigated sites with abnormal electroencephalogram and/or pathology show a unique blue shift in their fluorescence spectra, which is not seen in other cases.

Citation Download Citation

W.-C. Lin, J. Ragheb, S. Bhatia, Mahlon D. Johnson, D. Sandberg, A. Fernandez, G. Morrison, M. Duchowny, and P. Jayakar "In vivo optical characterization of pediatric epileptogenic lesions", Proc. SPIE 6424, Photonic Therapeutics and Diagnostics III, 642427 (23 March 2007); https://doi.org/10.1117/12.700717

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available