Quantifying mucosal blood volume fraction from multispectral images of the colon

Ela Claridge; Džena Hidović-Rowe; Phillipe Taniere; Tariq Ismail

doi:10.1117/12.709559

29 March 2007 Quantifying mucosal blood volume fraction from multispectral images of the colon

Ela Claridge, Džena Hidović-Rowe, Phillipe Taniere, Tariq Ismail

Proceedings Volume 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images; 65110C (2007) https://doi.org/10.1117/12.709559
Event: Medical Imaging, 2007, San Diego, CA, United States

Abstract

One of the common physiological changes associated with cancer is the formation of a dense, irregular and leaky network of new blood vessels, which result in the increase of the blood volume fraction (BVF) at the site of a tumour. Such changes are not always obvious through visual inspection using a direct observation, an endoscopic device or colour photography. This paper presents a method for deriving quantitative estimates of BVF of the colon mucosa from multispectral images of the colon. The method has two stages. In the first ("forward") stage a physics-based model of light propagation computes the spectra corresponding to a range of instances of the colon tissue, and in particular the spectral changes resulting from changes in the quantity of blood volume fraction, haemoglobin saturation, the size and density of scattering particles, and the tissue thickness. In the second stage ("model inversion") the spectra obtained from the image data are used to derive the values of the above histological parameters. Parametric maps of the blood contents are created by storing at every pixel the BVF value recovered through the model inversion. In a pilot study multispectral images of ex-vivo samples of the colon were acquired from 8 patients. The samples contained histologically confirmed instances of adenocarcinoma and other pathologies. The parametric maps of BVF showed the significant increase in blood volume fraction (up to 75% above that of the surrounding the normal tissue). A Mann-Whitney test with Bonferroni correction showed that all but one of the differences (a benign neoplastic polyp) are significant (p<0.00015).

Citation Download Citation

Ela Claridge, Džena Hidović-Rowe, Phillipe Taniere, and Tariq Ismail "Quantifying mucosal blood volume fraction from multispectral images of the colon", Proc. SPIE 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, 65110C (29 March 2007); https://doi.org/10.1117/12.709559

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