Three-dimensional image reconstruction for time-domain fluorescence molecular tomography based on generalized pulse spectrum technique

Limin Zhang; Feng Gao; Huiyuan He; Yiwen Ma; Pingqiao Ruan; Huijuan Zhao

doi:10.1117/12.754070

8 January 2008 Three-dimensional image reconstruction for time-domain fluorescence molecular tomography based on generalized pulse spectrum technique

Limin Zhang, Feng Gao, Huiyuan He, Yiwen Ma, Pingqiao Ruan, Huijuan Zhao

Author Affiliations +

Proceedings Volume 6826, Optics in Health Care and Biomedical Optics III; 68262I (2008) https://doi.org/10.1117/12.754070
Event: Photonics Asia 2007, 2007, Beijing, China

Abstract

A linear generalized pulse spectrum technique for image reconstruction of fluorescence molecular tomography is proposed. The algorithm employs a finite element method solution to the Laplace-transformed coupled diffusion equations and can simultaneously reconstruct both fluorescent yield and lifetime images of fluorophores. The proposed algorithm was validated using simulated data for 3D phantoms. We investigated the ability of the algorithm to reconstruct the fluorescent yield and lifetime at different region, contrasted the imaging quality of different target lifetime and proved the noise-robustness by using noisy data with different signal-to-noise ratio. The results show that the approach accurately retrieves the position and shape of the target and prove the effectiveness of the methodology.

Citation Download Citation

Limin Zhang, Feng Gao, Huiyuan He, Yiwen Ma, Pingqiao Ruan, and Huijuan Zhao "Three-dimensional image reconstruction for time-domain fluorescence molecular tomography based on generalized pulse spectrum technique", Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68262I (8 January 2008); https://doi.org/10.1117/12.754070

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KEYWORDS

Reconstruction algorithms

Detection and tracking algorithms

Luminescence

Signal to noise ratio

Diffusion

Image restoration

Atrial fibrillation

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