Can Raman spectroscopy identify the origin of Paget disease?

A. A. Martin; Moreno Marcelo; R. Bitar; H,. Martinho; E. A. P. Santos; E. A. L. Arisawa

doi:10.1117/12.760097

10 March 2008 Can Raman spectroscopy identify the origin of Paget disease?

A. A. Martin, Moreno Marcelo, R. Bitar, H,. Martinho, E. A. P. Santos, E. A. L. Arisawa

Proceedings Volume 6853, Biomedical Optical Spectroscopy; 685312 (2008) https://doi.org/10.1117/12.760097
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

The histogenesis of the breast Paget's disease was investigated by the optical diagnosis technique using Raman spectroscopy. A total of 15 spectra of the associated breast lesion, 21 spectra of the eczematoid skin lesion and 396 spectra of invasive breast cancer not otherwise specified were compared by clustering the spectral data between 800 - 1800 cm^-1 at level of similarity of 95%, using a correlation distance measurement by computing the covariance matrix. The Raman spectral-biochemical characterization of invasive breast cancer and breast Paget's disease with eczematoid skin lesion associated with underlying invasive breast lesion tissues enabled one concludes that the parenchymal disease had similar characteristics to the skin's Paget lesion. This could indicate a similar histogenesis for both. Thus, the findings of the present work adds a relevant experimental evidence that agrees with the epidermotropic theory of Paget's disease, that states that the cells originate in the breast ducts and migrate to the nipple's skin.

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A. A. Martin, Moreno Marcelo, R. Bitar, H,. Martinho, E. A. P. Santos, and E. A. L. Arisawa "Can Raman spectroscopy identify the origin of Paget disease?", Proc. SPIE 6853, Biomedical Optical Spectroscopy, 685312 (10 March 2008); https://doi.org/10.1117/12.760097

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KEYWORDS

Breast

Raman spectroscopy

Skin

Breast cancer

Tissues

Nipple

Remote sensing

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