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5 June 2008 Influence of vesicle size distribution on level and selectivity of accumulation of liposomal photosensitizer Tiosens in tumor
Gennady A. Meerovich, Igor G. Meerovich, Daria G. Gurevich, Sergey I. Vorobyov, Vyacheslav G. Pevgov, Zoya S. Smirnova, Natalia A. Oborotova, Evgeny A. Lukyanets, Victor B. Loschenov, Anatoly Yu. Baryshnikov
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Proceedings Volume 7022, Advanced Laser Technologies 2007; 702210 (2008) https://doi.org/10.1117/12.804091
Event: Advanced Laser Technologies 2007, 2007, Levi, Finland
Abstract
The work was performed to estimate the influence of liposomal size distribution on the level and selectivity of accumulation of photosensitizer of near-IR spectral range Tiosens (liposomal form of aluminium hydroxide phenylthiophthalocyanine) in tumor. Tiosens liposome dispersions were prepared using classic Bangham procedure. Particle size was reduced and unified using Avanti Mini-Extruder equipped with Nucleopore membranes and high-pressure homogenizer Donor-1. Liposomal size distribution was determined by means of laser correlation spectroscopy. Dynamics and selectivity of Tiosens accumulation in Erlich tumor were measured in vivo using fluorescence spectroscopy. It was shown that level and selectivity of accumulation of liposome-encapsulated drug is determined mostly by content of small-sized fractions, while fractions of larger size are quickly cleared from blood by RES and not contribute in photosensitizer accumulation.
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Gennady A. Meerovich, Igor G. Meerovich, Daria G. Gurevich, Sergey I. Vorobyov, Vyacheslav G. Pevgov, Zoya S. Smirnova, Natalia A. Oborotova, Evgeny A. Lukyanets, Victor B. Loschenov, and Anatoly Yu. Baryshnikov "Influence of vesicle size distribution on level and selectivity of accumulation of liposomal photosensitizer Tiosens in tumor", Proc. SPIE 7022, Advanced Laser Technologies 2007, 702210 (5 June 2008); https://doi.org/10.1117/12.804091
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KEYWORDS
Tumors
Laser spectroscopy
Tissues
In vivo imaging
Nanostructures
Spectroscopy
Aluminum
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