Porphyrin Fluorescence: Gross And Microscopic Localization

David M. Harris; James H. Hill

doi:10.1117/12.937320

10 March 1987 Porphyrin Fluorescence: Gross And Microscopic Localization

David M. Harris, James H. Hill

Proceedings Volume 0712, Lasers in Medicine; (1987) https://doi.org/10.1117/12.937320
Event: Cambridge Symposium-Fiber/LASE '86, 1986, Cambridge, MA, United States

Abstract

Hematoporphyrin derivative (HPD) is a mixture of porphyrins that localize in malignant tumors. The fluorescent emission of HPD was used in three animal tumor models to define tumor margins with gross imaging and to identify the microscopic distribution with fluores-cent photomicroscopy combined with standard histology. Fibroblasts within the tumor stroma were identified as the main cellular element retaining HPD. Our data indicate a barrier to diffusion of HPD containing it within the connective tissue capsule and preventing its up-take by malignant cells. A model for the uptake, retention and photodynamic action of HPD on tumors is proposed.

Citation Download Citation

David M. Harris and James H. Hill "Porphyrin Fluorescence: Gross And Microscopic Localization", Proc. SPIE 0712, Lasers in Medicine, (10 March 1987); https://doi.org/10.1117/12.937320

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