Second harmonic generation imaging of the collagen in myocardium for atrial fibrillation diagnosis

Ming-Rung Tsai; Yu-We Chiou; Chi-Kuang Sun

doi:10.1117/12.809950

23 February 2009 Second harmonic generation imaging of the collagen in myocardium for atrial fibrillation diagnosis

Ming-Rung Tsai, Yu-We Chiou, Chi-Kuang Sun

Proceedings Volume 7161, Photonic Therapeutics and Diagnostics V; 71612O (2009) https://doi.org/10.1117/12.809950
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Myocardial fibrosis, a common sequela of cardiac hypertrophy, has been shown to be associated with arrhythmias in experimental models. Some research has indicated that myocardial fibrosis plays an important role in predisposing patients to atrial fibrillation. Second harmonic generation (SHG) is an optically nonlinear coherent process to image the collagen network. In this presentation, we observe the SHG images of the collagen matrix in atrial myocardium and we analyzed of collagen fibers arrangement by using Fourier-transform analysis. Moreover, comparing the SHG images of the collagen fibers in atrial myocardium between normal sinus rhythm (NSR) and atrial fibrillation (AF), our result indicated that it is possible to realize the relation between myocardial fibrosis and AF.

Citation Download Citation

Ming-Rung Tsai, Yu-We Chiou, and Chi-Kuang Sun "Second harmonic generation imaging of the collagen in myocardium for atrial fibrillation diagnosis", Proc. SPIE 7161, Photonic Therapeutics and Diagnostics V, 71612O (23 February 2009); https://doi.org/10.1117/12.809950

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