Clinical system model for monitoring the physiological status of jaundice by extracting bilirubin components from skin diffuse reflectance spectra

Alla Suresh Kumar; Joseph Clark; Fred R. Beyette Jr.

doi:10.1117/12.808573

23 February 2009 Clinical system model for monitoring the physiological status of jaundice by extracting bilirubin components from skin diffuse reflectance spectra

Alla Suresh Kumar, Joseph Clark, Fred R. Beyette Jr.

Author Affiliations +

Proceedings Volume 7169, Advanced Biomedical and Clinical Diagnostic Systems VII; 716908 (2009) https://doi.org/10.1117/12.808573
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

Neonatal jaundice is a medical condition which occurs in newborns as a result of imbalance between the production and elimination of bilirubin. The excess bilirubin in the blood stream diffuses into the surrounding tissue leading to a yellowing of the skin. As the bilirubin levels rise in the blood stream, there is a continuous exchange between the extra vascular bilirubin and bilirubin in the blood stream and exposure to phototherapy also alters the process. Diffuse reflectance spectra from human skin contains physiological and structural information of human skin and nearby tissue. Blanching, a phenomenon in which a slight capillary closure pressure is applied to force the blood under the applied area. A diffuse reflectance spectrum has to be captured before and after blanching to isolate the intravascular and extra vascular bilirubin.A new mathematical model is proposed with extra vascular bilirubin concentration taken into consideration along with other optical parameters in defining the diffuse reflectance spectrum of human skin. Nonlinear Optimization and Genetic Algorithms have been adopted to extract the optical properties (bilirubin concentration) from reflectance spectrum of skin. Bilirubin components were extracted from simulated diffuse reflectance spectrum within an average error of 10%

Citation Download Citation

Alla Suresh Kumar, Joseph Clark, and Fred R. Beyette Jr. "Clinical system model for monitoring the physiological status of jaundice by extracting bilirubin components from skin diffuse reflectance spectra", Proc. SPIE 7169, Advanced Biomedical and Clinical Diagnostic Systems VII, 716908 (23 February 2009); https://doi.org/10.1117/12.808573

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available