Conjugate systems using delocalized cationic dyes as a carrier of photosensitizers to mitochondria

Youngjae You; Ethel J. Ngen; Pallavi Rajaputra

doi:10.1117/12.823010

13 July 2009 Conjugate systems using delocalized cationic dyes as a carrier of photosensitizers to mitochondria

Youngjae You, Ethel J. Ngen, Pallavi Rajaputra

Proceedings Volume 7380, Photodynamic Therapy: Back to the Future; 738064 (2009) https://doi.org/10.1117/12.823010
Event: 12th World Congress of the International Photodynamic Association, 2009, Seattle, Washington, United States

Abstract

Following Photofrin, the first generation photosensitizer, several second generation photosensitizers have been developed with improved characteristics. More recently, third generation photosensitizers are proposed to achieve higher selectivity toward cancer cells/ tumor tissue. Elevated mitochondrial membrane potential of malignant cells has tested as a tool for preferential uptake of certain photosensitizers to cancer cells. In the same line, we designed new conjugate systems where delocalized cationic moiety delivers a photosensitizer to mitochondria. To prove our concept, two prototype conjugates (TPP-Rh and TPP-AO) were prepared using two cationic dyes (Rhodamine and Acridine Orange) and a photosensitizer (tetraphenylporphyrin, TPP). The two conjugates generated singlet oxygen quite well. Interestingly, the two conjugates showed higher cellular uptake by mover than 8 times than TPP-OH as well as higher phototoxicity. In particular, TPP-Rh showed closer localization pattern to mitochondria than TPP-OH.

Citation Download Citation

Youngjae You, Ethel J. Ngen, and Pallavi Rajaputra "Conjugate systems using delocalized cationic dyes as a carrier of photosensitizers to mitochondria", Proc. SPIE 7380, Photodynamic Therapy: Back to the Future, 738064 (13 July 2009); https://doi.org/10.1117/12.823010

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