New scheme for polarimetric glucose sensing without polarizers

Amy M. Winkler; Garret T. Bonnema; Jennifer K. Barton

doi:10.1117/12.842482

25 February 2010 New scheme for polarimetric glucose sensing without polarizers

Amy M. Winkler, Garret T. Bonnema, Jennifer K. Barton

Proceedings Volume 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics; 757204 (2010) https://doi.org/10.1117/12.842482
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Polarimetric glucose sensing is a promising method for noninvasive estimation of blood glucose concentration. Published methods of polarimetric glucose sensing generally rely on measuring the rotation of light as it traverses the aqueous humor of the eye. In this article, an interferometer is described that can detect polarization changes due to glucose without the use of polarization control or polarization analyzing elements. Without polarizers, this system is sensitive to optical activity, inherent to glucose, but minimally sensitive to linear retardance, inherent to the cornea. The underlying principle of the system was experimentally verified using spectral domain optical coherence tomography. A detection scheme involving amplitude modulation was simulated, demonstrating sensitivity to clinically relevant glucose concentrations and an acceptable error due to time varying linear birefringence of the cornea using Clarke Error Grid Analysis.

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Amy M. Winkler, Garret T. Bonnema, and Jennifer K. Barton "New scheme for polarimetric glucose sensing without polarizers", Proc. SPIE 7572, Optical Diagnostics and Sensing X: Toward Point-of-Care Diagnostics, 757204 (25 February 2010); https://doi.org/10.1117/12.842482

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KEYWORDS

Glucose

Wave plates

Birefringence

Modulation

Polarimetry

Polarization

Polarizers

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