Synthesis, optical and microscopical characterization of albumin/porous silica/gold nanorods

Fulvio Ratto; Sonia Centi; Paolo Matteini; Francesca Rossi; Roberto Pini

doi:10.1117/12.840963

16 February 2010 Synthesis, optical and microscopical characterization of albumin/porous silica/gold nanorods

Fulvio Ratto, Sonia Centi, Paolo Matteini, Francesca Rossi, Roberto Pini

Proceedings Volume 7577, Plasmonics in Biology and Medicine VII; 757715 (2010) https://doi.org/10.1117/12.840963
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

We describe the synthesis of novel hybrid nanoparticles composed of a gold nanorods core and a bovine serum albuminconjugated porous silica shell. The pores of the porous silica shell are loaded with the cytotoxic surfactant cetrimonium bromide. Throughout the various steps of the synthesis, these nanoparticles exhibit excellent light extinction in a near infrared window around 700 - 900 nm, and good colloidal stability in aqueous environment. On replacement of the bovine serum albumin and cetrimonium bromide with functional macromolecules (e.g. antibodies) and appropriate drugs, this architecture may find application in a variety of biomedical applications including optical and photoacoustic diagnoses and imaging, photothermal and photoacoustic therapies and controlled drug release.

Citation Download Citation

Fulvio Ratto, Sonia Centi, Paolo Matteini, Francesca Rossi, and Roberto Pini "Synthesis, optical and microscopical characterization of albumin/porous silica/gold nanorods", Proc. SPIE 7577, Plasmonics in Biology and Medicine VII, 757715 (16 February 2010); https://doi.org/10.1117/12.840963

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KEYWORDS

Gold

Nanorods

Nanoparticles

Near infrared

Silica

Biomedical optics

Transmission electron microscopy

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