Simultaneous imaging of light-evoked activities in retinal photoreceptors and inner neurons

Xin-Cheng Yao; Yi-Chao Li; Christianne Strang; Franklin R. Amthor; Lei Liu; Yang-Guo Li; Qiuxiang Zhang; Kent Keyser

doi:10.1117/12.875289

18 February 2011 Simultaneous imaging of light-evoked activities in retinal photoreceptors and inner neurons

Xin-Cheng Yao, Yi-Chao Li, Christianne Strang, Franklin R. Amthor, Lei Liu, Yang-Guo Li, Qiuxiang Zhang, Kent Keyser

Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 78834U (2011) https://doi.org/10.1117/12.875289
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Simultaneous imaging of different retinal neurons functioning together can benefit better understanding of visual signal processing mechanisms. In this paper we demonstrate that intrinsic optical signal (IOS) imaging allows simultaneous monitoring of stimulus-evoked responses propagating from the photoreceptors to inner retinal neurons. High resolution imaging revealed robust IOSs at the photoreceptor, inner plexiform and ganglion cell layers. While IOSs of the photoreceptor layer were mainly confined to the area directly stimulated by the visible light; IOSs of inner retinal layers spread from the stimulus site into relatively large areas.

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Xin-Cheng Yao, Yi-Chao Li, Christianne Strang, Franklin R. Amthor, Lei Liu, Yang-Guo Li, Qiuxiang Zhang, and Kent Keyser "Simultaneous imaging of light-evoked activities in retinal photoreceptors and inner neurons", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78834U (18 February 2011); https://doi.org/10.1117/12.875289

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