Paper
22 February 2011 Reduction of noise floor for molecular, fluorescence-enhanced optical imaging
Author Affiliations +
Abstract
Near infrared fluorescence (NIRF) optical imaging has been successfully demonstrated to offer a high specificity and sensitivity in detecting various diseases. However, the measurement sensitivity of NIRF optical imaging system is limited by strong backscattered excitation light leakage. Herein, appropriate filter combination and collimation optics was adapted to the NIRF optical imager. The sensitivity of near-infrared fluorescence imaging instrumentation can be dramatically improved upon using the appropriate filter combination and collimation optics. This validation and qualification approach to reduce the noise floor and improve sensitivity is presented a standardized metric for all fluorescence based imaging systems proposed.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Banghe Zhu, John C. Rasmussen, Yujie Lu, and Eva M. Sevick-Muraca "Reduction of noise floor for molecular, fluorescence-enhanced optical imaging", Proc. SPIE 7891, Design and Quality for Biomedical Technologies IV, 789104 (22 February 2011); https://doi.org/10.1117/12.874331
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CITATIONS
Cited by 2 scholarly publications.
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KEYWORDS
Optical filters

Image filtering

Luminescence

Imaging systems

Optical imaging

Collimation

Signal to noise ratio

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