Optical coherence tomography image enhancement by using gold nanoparticles

Y. R. Ponce-de-Leon; J. A. Lopez-Rios; J. L. Pichardo-Molina; N. Alcalá Ochoa

doi:10.1117/12.902773

2 November 2011 Optical coherence tomography image enhancement by using gold nanoparticles

Y. R. Ponce-de-Leon, J. A. Lopez-Rios, J. L. Pichardo-Molina, N. Alcalá Ochoa

Proceedings Volume 8011, 22nd Congress of the International Commission for Optics: Light for the Development of the World; 80118W (2011) https://doi.org/10.1117/12.902773
Event: International Commission for Optics (ICO 22), 2011, Puebla, Mexico

Abstract

Optical Coherence Tomography (OCT) is an imaging technique to get cross-sectional images with resolutions of a few microns and deep penetration in tissue of some millimeters. For many years OCT has been applied to analyze different human tissues like eyes, skin, teeth, urinary bladders, gastrointestinal, respiratory or genitourinary tracts and recently breast cancer tissues have been studied. Many of these tissues are composed specially of lipids and collagen, proteins which cause multiple light scattering (MLS) reducing significantly the optical depth and the contrast of OCT imaging. So, one of the big challenges of this technique is to acquire images with good contrast. Gold nanoparticles (NPs) exhibit interesting optical properties due to its plasmon resonance frequency. Optical absorbance is strong when gold NPs have dimension under 50 nm, but over this size optical scattering becomes dominant. In this work we show the preliminary results of the use of gold NPs as a contrast medium to enhance the OCT images quality. Our experimental results show which type of particles (morphology and size) present the best enhancement in the region of 1325 nm which corresponds to the central wavelength source excitation. All our experiments were carried out with a commercial OCT (thorlabs) system and our NPs were tested in water and gel phantoms.

Citation Download Citation

Y. R. Ponce-de-Leon, J. A. Lopez-Rios, J. L. Pichardo-Molina, and N. Alcalá Ochoa "Optical coherence tomography image enhancement by using gold nanoparticles", Proc. SPIE 8011, 22nd Congress of the International Commission for Optics: Light for the Development of the World, 80118W (2 November 2011); https://doi.org/10.1117/12.902773

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