Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection

Shanshan Liang; Arya Saidi; Joe Jing; Gangjun Liu; Jiechen Yin; Jagat Narula; Zhongping Chen

doi:10.1117/12.907836

9 February 2012 Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection

Shanshan Liang, Arya Saidi, Joe Jing, Gangjun Liu, Jiechen Yin, Jagat Narula, Zhongping Chen

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82073Y (2012) https://doi.org/10.1117/12.907836
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Coronary heart disease (like myocardial infarction) is caused by atherosclerosis. It cause over 30% of all deaths in North America and are the most common cause of death in European men under 65 years of age and the second most common cause in women. To diagnose this atherosclerosis before it gets rupture is the most effect way to increase the chance of survival for patients who suffer from this disease. The crucial tusk is how to find out vulnerable plaques. In resent years optical coherence tomography (OCT) has become a very useful tool for intravascular imaging, since it has high axial and transverse resolution. OCT can tell the detail structure inside the plaque like the thickness of plaque cap which is an important factor to identify vulnerable plaques. But we still need to find out the biochemical characteristics that is unique for vulnerable plaques (like inflammation). Fluorescence molecular imaging is a standard way to exam the biochemical property of biological samples. So we integrate these two techniques together into one probe. Our probe is comprised of a double-clad fiber (DCF) and a grin lens, and rotates with a micro mirror in front. The single-mode inner core of the DCF transmits both OCT and fluorescence excitation light, and the multimode inner cladding is used to detect fluorescence signal. In vitro result shows that this is a possible way for more accurate diagnose of vulnerable plaques.

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Shanshan Liang, Arya Saidi, Joe Jing, Gangjun Liu, Jiechen Yin, Jagat Narula, and Zhongping Chen "Combining OCT and a fluorescence intensity imaging method for atherosclerosis detection", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82073Y (9 February 2012); https://doi.org/10.1117/12.907836

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KEYWORDS

Optical coherence tomography

Luminescence

Arteries

Diagnostics

Signal detection

Tissues

Intravascular ultrasound

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