Microfluidics analysis of blood using joint spectral and time domain optical coherence tomography

Danuta Bukowska; Maciej Szkulmowski; Iwona Gorczynska; Andrzej Kowalczyk; Maciej Wojtkowski

doi:10.1117/12.911070

17 February 2012 Microfluidics analysis of blood using joint spectral and time domain optical coherence tomography

Danuta Bukowska, Maciej Szkulmowski, Iwona Gorczynska, Andrzej Kowalczyk, Maciej Wojtkowski

Proceedings Volume 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI; 82132R (2012) https://doi.org/10.1117/12.911070
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Although the Doppler Optical Coherence Tomography techniques have already enabled imaging of blood flow in large vessels in biological tissues, the generation of velocity maps of the capillary network is still a challenge. Since several important physiological and pathological phenomena occur in the microcirculation, the possibility of flow imaging and velocity assessment in microcapillaries may be important for medical diagnostics. Understanding of the origin of the Doppler signal in capillary vessels and limitations of such measurements is essential for further development of Doppler OCT methods. In the OCT flow maps of a microcapillary network randomly varying Doppler signals are observed. To answer the question how accurate is the Doppler OCT flow measurement for blood motion in small vessels, we have investigated the possibility to obtain velocity profiles of blood in vitro in well controlled experimental configuration. We have used a rectangular microchannel (100 μm wide, 40 μm deep) as a microcapillary phantom. Imaging was performed with a Fourier domain OCT setup with a CMOS camera. Data analysis was performed using joint Spectral and Time Domain OCT method (STdOCT).

Citation Download Citation

Danuta Bukowska, Maciej Szkulmowski, Iwona Gorczynska, Andrzej Kowalczyk, and Maciej Wojtkowski "Microfluidics analysis of blood using joint spectral and time domain optical coherence tomography", Proc. SPIE 8213, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI, 82132R (17 February 2012); https://doi.org/10.1117/12.911070

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KEYWORDS

Optical coherence tomography

Doppler tomography

Blood

Biomedical optics

Blood circulation

Doppler effect

Microfluidics

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