Three-dimensional calibration targets for optical coherence tomography

Michelle Gabriele Sandrian; Pete Tomlins; Peter Woolliams; Janarthanan Rasakanthan; Graham CB Lee; Anna Yang; Boris Považay; Aneesh Alex; Kate Sugden; Wolfgang Drexler

doi:10.1117/12.907748

2 February 2012 Three-dimensional calibration targets for optical coherence tomography

Michelle Gabriele Sandrian, Pete Tomlins, Peter Woolliams, Janarthanan Rasakanthan, Graham CB Lee, Anna Yang, Boris Považay, Aneesh Alex, Kate Sugden, Wolfgang Drexler

Author Affiliations +

Proceedings Volume 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV; 822914 (2012) https://doi.org/10.1117/12.907748
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

The recent expansion of clinical applications for optical coherence tomography (OCT) is driving the development of approaches for consistent image acquisition. There is a simultaneous need for time-stable, easy-to-use imaging targets for calibration and standardization of OCT devices. We present calibration targets consisting of three-dimensional structures etched into nanoparticle-embedded resin. Spherical iron oxide nanoparticles with a predominant particle diameter of 400 nm were homogeneously dispersed in a two part polyurethane resin and allowed to harden overnight. These samples were then etched using a precision micromachining femtosecond laser with a center wavelength of 1026 nm, 100kHz repetition rate and 450 fs pulse duration. A series of lines in depth were etched, varying the percentage of inscription energy and speed of the translation stage moving the target with respect to the laser. Samples were imaged with a dual wavelength spectral-domain OCT system (λ=800nm, ▵λ≈180nm, and λ=1325nm, ▵λ≈100nm) and point-spread function of nanoparticles within the target was measured.

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Michelle Gabriele Sandrian, Pete Tomlins, Peter Woolliams, Janarthanan Rasakanthan, Graham CB Lee, Anna Yang, Boris Považay, Aneesh Alex, Kate Sugden, and Wolfgang Drexler "Three-dimensional calibration targets for optical coherence tomography", Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 822914 (2 February 2012); https://doi.org/10.1117/12.907748

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