Coloring brain tumor with multi-potent micellar nanoscale drug delivery system

Kyuha Chong M.D.; Kyungsun Choi; EunSoo Kim; Eun Chun Han; Jungsul Lee; Junghwa Cha; Taeyun Ku; Jonghee Yoon; Ji Ho Park; Chulhee Choi

doi:10.1117/12.946103

24 October 2012 Coloring brain tumor with multi-potent micellar nanoscale drug delivery system

Kyuha Chong M.D., Kyungsun Choi, EunSoo Kim, Eun Chun Han, Jungsul Lee, Junghwa Cha, Taeyun Ku, Jonghee Yoon, Ji Ho Park, Chulhee Choi

Author Affiliations +

Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 85480I (2012) https://doi.org/10.1117/12.946103
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of

Abstract

Brain tumor, especially glioblastoma multiforme (GBM), is one of the most malignant tumors, which not only demands perplexing treatment approaches but also requires potent and effective treatment modality to deal with recurrence of the tumor. Photodynamic therapy (PDT) is a treatment which has been recommended as a third-level treatment. We are trying to investigate possibility of the PDT as an efficient adjuvant therapeutic modality for the treatment of brain tumor. Inhibition of tumor progression with photosensitizer was verified, in vitro. With micellar nanoscale drug delivery system, localization of the tumor was identified, in vivo, which is able to be referred as photodynamic diagnosis. With consequent results, we are suggesting photodynamic diagnosis and therapy is able to be performed simultaneously with our nanoscale drug delivery system.

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Kyuha Chong M.D., Kyungsun Choi, EunSoo Kim, Eun Chun Han, Jungsul Lee, Junghwa Cha, Taeyun Ku, Jonghee Yoon, Ji Ho Park, and Chulhee Choi "Coloring brain tumor with multi-potent micellar nanoscale drug delivery system", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85480I (24 October 2012); https://doi.org/10.1117/12.946103

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