Near infrared spectral polarization imaging of prostate cancer tissues
using Cybesin: a receptor-targeted contrast agent

Yang Pu; W. B. Wang; G. C. Tang; Kexian Liang; S. Achilefu; R. R. Alfano

doi:10.1117/12.2000079

8 March 2013 Near infrared spectral polarization imaging of prostate cancer tissues using Cybesin: a receptor-targeted contrast agent

Yang Pu, W. B. Wang, G. C. Tang, Kexian Liang, S. Achilefu, R. R. Alfano

Author Affiliations +

Proceedings Volume 8565, Photonic Therapeutics and Diagnostics IX; 85651G (2013) https://doi.org/10.1117/12.2000079
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

Cybesin, a smart contrast agent to target cancer cells, was investigated using a near infrared (NIR) spectral polarization imaging technique for prostate cancer detection. The approach relies on applying a contrast agent that can target cancer cells. Cybesin, as a small ICG-derivative dye-peptide, emit fluorescence between 750 nm and 900 nm, which is in the “tissue optical window”. Cybesin was reported targeting the over-expressed bombesin receptors in cancer cells in animal model and the human prostate cancers over-expressing bombesin receptors. The NIR spectral polarization imaging study reported here demonstrated that Cybesin can be used as a smart optical biomarker and as a prostate cancer receptor targeted contrast agent.

Citation Download Citation

Yang Pu, W. B. Wang, G. C. Tang, Kexian Liang, S. Achilefu, and R. R. Alfano "Near infrared spectral polarization imaging of prostate cancer tissues using Cybesin: a receptor-targeted contrast agent", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85651G (8 March 2013); https://doi.org/10.1117/12.2000079

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KEYWORDS

Tissues

Prostate

Receptors

Prostate cancer

Polarization

Luminescence

Near infrared

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