New nonlinear inversion technique for depth distribution of absorption using spatially resolved backscattering measurement

Kazuhiro Nishida; Takeshi Namita; Yuji Kato; Koichi Shimizu

doi:10.1117/12.2002794

25 March 2013 New nonlinear inversion technique for depth distribution of absorption using spatially resolved backscattering measurement

Kazuhiro Nishida, Takeshi Namita, Yuji Kato, Koichi Shimizu

Author Affiliations +

Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85782X (2013) https://doi.org/10.1117/12.2002794
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

To estimate the depth distribution of the absorption coefficient in a turbid medium, a new nonlinear inversion technique was developed. It can resolve important shortcomings of the nonlinear error of conventional linear inversion techniques. First, a turbid medium is divided into imaginary layers with arbitrary thickness. The spatial pathlength distribution (SPD) is obtained for each layer in the Monte Carlo simulation as a function of source-detector distance. In the integral operation using SPDs, we can obtain the absorption coefficient of each layer, or the depth distribution of absorption. This inversion process is based on the assumption that the light attenuation is linear with respect to the small pathlength of a photon. However, if we consider the variance of pathlength of many photons in each layer, then this assumption produces nonlinear error. We developed a technique to solve this problem in the following three steps. First, the initial values of absorption coefficient of each layer are obtained using a conventional linear inverse matrix assuming that variance of pathlength of many photons does not exist. Then, improved absorption coefficients are obtained with these initial values and the pathlength variance of many photons using the same matrix. In this way, the nonlinear error is corrected. Repeating this process, the improved absorption coefficient approaches a true value. The effectiveness of the proposed technique was confirmed in the Monte Carlo simulation. The effect of measurement noise was analyzed in the simulation.

Citation Download Citation

Kazuhiro Nishida, Takeshi Namita, Yuji Kato, and Koichi Shimizu "New nonlinear inversion technique for depth distribution of absorption using spatially resolved backscattering measurement", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85782X (25 March 2013); https://doi.org/10.1117/12.2002794

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available