Single wall carbon nanotube/bis carboxylic acid-ICG as a
sensitive contrast agent for in vivo tumor imaging in
photoacoustic tomography

Saeid Zanganeh; Hai Li; Patrick Kumavor; Umar Alqasemi; Andres Aguirre; Innus Mohammad; Courtney Stanford; Michael B. Smith; Quing Zhu

doi:10.1117/12.2008179

4 March 2013 Single wall carbon nanotube/bis carboxylic acid-ICG as a sensitive contrast agent for in vivo tumor imaging in photoacoustic tomography

Saeid Zanganeh, Hai Li, Patrick Kumavor, Umar Alqasemi, Andres Aguirre, Innus Mohammad, Courtney Stanford, Michael B. Smith, Quing Zhu

Author Affiliations +

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 85814R (2013) https://doi.org/10.1117/12.2008179
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

In this study, we present a novel photoacoustic contrast agent which is based on bis-carboxylic acid derivative of Indocyanine green (ICG) covalently conjugated to single-wall carbon nanotubes (ICG/SWCNT). Covalently attaching ICG to the functionalized SWCNT provides a more robust system that delivers much more ICG to the tumor site. The detection sensitivity of the new contrast agent in mouse tumor model is demonstrated in vivo by our custom built photoacoustic imaging system. PAT summation signal is defined to show the long-term light absorption of tumor areas in ICG injected mice and ICG/SWCNT injected mice. It is shown that ICG is able to provide 33% enhancement at approximately 20 minutes peak response time referred to pre-injection PAT summation level, while ICG/SWCNT provides 128% enhancement at 80 minutes and even higher enhancement of 196% at the end point of experiments (120 minutes on average). Additionally, the ICG/SWCNT enhancement was mainly observed at the tumor periphery as confirmed by fluorescence images of the tumor samples. This feature is highly valuable in guiding surgeons to assess tumor boundaries and dimensions in vivo and improve surgical resection of tumors for achieving clean tumor margins.

Citation Download Citation

Saeid Zanganeh, Hai Li, Patrick Kumavor, Umar Alqasemi, Andres Aguirre, Innus Mohammad, Courtney Stanford, Michael B. Smith, and Quing Zhu "Single wall carbon nanotube/bis carboxylic acid-ICG as a sensitive contrast agent for in vivo tumor imaging in photoacoustic tomography", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 85814R (4 March 2013); https://doi.org/10.1117/12.2008179

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